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Original Research, Pharmacology/Drug Development, Itch

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Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.

Voltage-gated sodium channel Nav1.7 has been validated as a perspective target for selective inhibitors with analgesic and anti-itch activity. The objective of this study was to discover new candidate compounds with Nav1.7 inhibitor properties. The authors hypothesized that their approach would yield at least one new compound that inhibits sodium currents in vitro and exerts analgesic and anti-itch effects in mice.

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