-IASP Virtual Series on Pain & Expo: Pharmacokinetic and Pharmacodynamic Considerations in Animal and Human Analgesic Studies

January 28, 2021

This workshop will provide an introduction on the importance of pharmacokinetic (PK) and pharmacodynamic (PD) considerations in studies of analgesic medications in animals and humans. Drug PK parameters determine the concentration of a drug in plasma, and in the tissue of interest. The relationship between a drug’s concentration at its cellular/molecular target, and its pharmacological effect (i.e. pharmacodynamics) are critically important for determining the efficacy and safety profiles of each drug. Unfortunately, in pain research in general, and in preclinical research in particular, comprehensive pharmacokinetic characterization of experimental drugs is seldom performed, while claims of efficacy and safety are being made. The speakers will provide an overview of fundamental principles of pharmacokinetics and pharmacodynamics, and will present examples to help the attendees understand how PK and PD parameters are calculated, estimated or obtained empirically. In addition, through

9:00-10:30 ET