About IASP Membership Meetings Publications Chapters SIGs Grants Resources Professional Development
Attention IASP Members:
Pay Your Dues Online

Interested in Joining?
Learn about Membership
 Apply Online Now!
Print This Page

Text Only Site

Immune and Glial Regulation of Pain

 Image

Editors: Joyce A. DeLeo, Linda S. Sorkin, and Linda R. Watkins

publish year: 2007
hardcover with CD-ROM
443 pages
ISBN 78-0-931092-67-1

 

Table of Contents
Write a Review

List Price: US$75.00
IASP members: US$60.00

Buy Now

 

We need your feedback!

This book includes our first-ever CD-ROM.  IASP Press is pleased to offer this additional feature, and we would appreciate your  comments, suggestions, or other feedback on the CD-ROM.

If you have purchased this book and reviewed the CD-ROM, would you please take a moment to complete a short, seven-question survey?

Simply click here go to the Survey and tell us what you think of the CD-ROM.


  • An up-to-date review of the role of immune and glial factors in pain etiology
  • Immune-pain interactions in peripheral tissues and the central nervous system
  • The role of cytokines in neuropathic pain
  • Morphine tolerance and glial-pain interactions
  • New immune and glial targets for clinical pain control

Immune and Glial Regulation of Pain describes immune and glial factors within the peripheral and central nervous systems that relate to chronic pain states.  This authoritative volume describes immune-pain interactions in the peripheral tissues, nerves, dorsal root ganglia, and the spinal cord and brain and identifies novel immune and glial targets for clinical pain control that may yield new analgesic drugs.  Both clinicians and basic scientists will find this volume essential for an up-to-date review of this rapidly progressing field.

Table of Contents

List of Contributing Authors  vii
Preface    xi

Part I  Overview of Immune Cells and Glial Cells
1.  Immune Cells in Peripheral Nerve (Linda S. Sorkin and Maria Schäfers)
2. Roles of Astrocytes and Microglia in Pain Memory (Leif Hertz and Elisabeth Hansson)
3.  Intracellular Signaling Cascades in Glia (Etty N. Benveniste)
Part II  Immune-Pain Interactions: Peripheral Tissue and Nerves
4. Pain Facilitation by Proinflammatory Cytokine Actions at Peripheral Nerve Terminals (Thiago M. Cunha, Waldiceu A. Verri, Jr., Stephen Poole, Carlos A. Parada, Fernando Q. Cunha, and Sergio H. Ferreira) 
5.  Proinflammatory Cytokines and Neuropathic Pain: Retrograde Signaling and Dorsal Root Ganglion Changes after Peripheral Nerve Injury (Maria Schäfers, Claudia Sommer, and Linda S. Sorkin) 
6.  Analgesic Effects of Immune-Cell-Derived Opioids (Halina Machelska and Christoph Stein)
Part III  Immune/Glial-Pain Interactions: Dorsal Root Ganglia
7.  Chemokines and Their Receptors in the Nervous System: A Link to Neuropathic Pain (Fletcher A. White, Patrick E. Monahan, and Robert H. LaMotte)
8.  Electrophysiological Evidence of Enhanced Nociceptive Transmission in Response to Dorsal Root Exposure to Nucleus Pulposus (Jason M. Cuellar and E. Carstens )
9.  Peripheral Nerve Injury and Protection by Erythropoietin: Dorsal Root Ganglion Signaling Cascades and Chronic Pain (W. Marie Campana)
10.   Inflammation of Dorsal Root Ganglia: Satellite Cell Activation and ImmuneCell Recruitment after Nerve Injury (Elspeth M. McLachlan and Ping Hu)
Part IV  Glial Regulation of Neuronal Functions Relevant to Pain
11.  Cytokine Regulation of Ion Channels in the Pain Pathway (Maria Elena P. Morales and Robert W. Gereau IV)
12.   AMPAR Synaptic and Surface Localization Is Altered by Glial-Derived Tumor Necrosis Factor Alpha: Relevance to Hyperalgesia and Central Sensitization (Eric C. Beattie and David Stellwagen)
13.  Astrocyte Signaling Systems in Physiology and Pathology (Biljana Djukic, Todd Fiacco and Ken D. McCarthy)
Part V  Glial-Pain Interactions: Spinal Cord and Brain
14.  Steroid Hormone Regulation of Astrocyte Function: Implications for Central Nervous System Sensitization (Michael L. LaCroix-Fralish and Joyce A. DeLeo )
15.  The Role of ERK/MAPK in Spinal Glia for Neuropathic Pain: Signal Transduction in Spinal Microglia and Astrocytes after Nerve Injury (Ru-Rong Ji)
 
16.  The Role of ATP and Microglia in Enhanced Pain States (Simon Beggs, Tuan Trang, and Michael W. Salter)
17.  The Role of p38 in Microglial Regulation of Spinal Pain Processing (Camilla I. Svensson, Tony L. Yaksh, and Linda S. Sorkin) 
18.  Glially Driven Enhancement of Pain and Its Control by Anti-Inflammatory Cytokines (Erin D. Milligan, Annemarie Ledeboer, Evan M. Sloane, Steven M. Maier, David A. Busha, and Linda R. Watkins)
Part VI  Glial-Pain Interactions: Morphine Tolerance
19.  Modulating Glial Activation in Opioid Tolerance and Neuropathic Pain: A Role for Glutamate Transporters (Vivianne L. Tawfik and Joyce A. DeLeo) 
20.  Proinflammatory Cytokines Modulate Neuropathic Pain, Opioid Analgesia, and Opioid Tolerance (Yehuda Shavit, Gilly Wolf, Ian N. Johnston, R. Frederick Westbrook, Linda R. Watkins, and Raz Yirmiya)
Part  VII  Immune and Glial Interactions with Pain: Implications for Clinical Pain Control
21.  New Perspectives on Sciatica (Jaro Karppinen)
22.  Immunomodulatory Therapies for Complex Regional Pain Syndrome: Thalidomide and Beyond (Donald C. Manning)
23.  Cytokine Profiles in Patients with Chronic Widespread Pain (Nurcan Üçeyler and Claudia Sommer)
  Index